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Article

Pre-stroke physical activity and Val66Met (rs6265) genotype of BDNF gene correlate with the post-stroke cognitive outcome: a prospective cohort study.

Experimental brain research - 27 May 2026

Kotlega Dariusz, Peda Barbara, Zembron-Lacny Agnieszka, Baldy-Chudzik Katarzyna, Wawrzyniak-Gramacka Edyta, Szczuko Malgorzata

Abstract excerpt

Pre-stroke physical activity may protect against post-stroke cognitive impairment (PSCI) via neuroplastic mechanisms including BDNF signalling. However, evidence in stroke survivors and the modifying role of the BDNF Val66Met polymorphism remain limited. In this prospective single-centre cohort, 97 patients with ischaemic stroke underwent detailed neuropsychological assessment during index hospitalisation and at...

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Identifiers

PMID: 42201389
DOI: 10.1007/s00221-026-07325-7
PMCID: PMC13216174

Genes

BDNF
MET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Pre-stroke physical activity and Val66Met (rs6265) genotype of BDNF gene correlate with the post-stroke cognitive outcome: a prospective cohort study.PMID 42201389Read ↗

Pre-stroke physical activity and Val66Met (rs6265) genotype of <i>BDNF</i> gene correlate with the post-stroke cognitive outcome: a prospective cohort studySemantic proximity Read ↗

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BDNF (rs6265) Val < Met polymorphism can buffer cognitive functions against post stroke CT/MRI pathological findings.Semantic proximity Read ↗

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BDNF Met allele Is Associated With Lower Cognitive Function in Poststroke Rehabilitation.Semantic proximity Read ↗

The implication of BDNF Val66Met polymorphism in progression from subjective cognitive decline to mild cognitive impairment and Alzheimer’s disease: a 9-year follow-up studySemantic proximity Read ↗

Role of BDNF val66met polymorphism on the association between physical activity and incident dementia.Semantic proximity Read ↗

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