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Article

A comparative approach for selecting orthologous candidate genes in genome-wide association studies across multiple species.

Plant physiology - 2 Jul 2026

Whitt Lauren, Mahood Elizabeth H, Ziegler Greg, Luebbert Collin, Gillman Jason D, Norton Gareth J, Price Adam H, Salt David E, Dilkes Brian P, Baxter Ivan

Abstract excerpt

Advances in quantitative genetics have enabled researchers to identify genomic regions associated with changes in phenotype. However, these regions can contain hundreds to thousands of genes, and progressing from genomic regions to causative genes is still challenging. In genome-wide association studies (GWAS) measuring elemental accumulation (ionomic) traits, only 5% of loci contain orthologs of genes known to...

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PMID: 42184341
DOI: 10.1093/plphys/kiag298
PMCID: PMC13353110

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