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Article

Integrative analysis of toxin-antitoxin systems, genomics, and phenotypic traits reveal phylogroup-dependent diversity among ExPEC bloodstream isolates.

International journal of medical microbiology : IJMM - 1 Jun 2026

Mitsunari Thais, Silva Jessika C A, Del Carpio Alejandra M G, Miranda Kaique F, MØller-Jensen Jakob, Kirkpatrick Clare L, Henrique Camila, Freire Claudia A, Domingos Marta O, Silva Rosa M, Elias Waldir P, Munhoz Danielle D, Carvalho Eneas, Piazza Roxane M F

Abstract excerpt

Extraintestinal pathogenic Escherichia coli (ExPEC) causing bloodstream infections encompass diverse evolutionary lineages with distinct genomic and pathogenic traits. Here, we applied an integrative strategy combining population-level analysis of type II toxin-antitoxin (TA) systems, comparative genomics, and phenotypic assays to explore ExPEC diversity. Screening of 85 ExPEC bloodstream isolates revealed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42176355
DOI: 10.1016/j.ijmm.2026.151721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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