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Article

Heat stroke management: clinical phenotypes and implications for cooling strategies.

Journal of translational medicine - 20 May 2026

Chen Lan, Wu Sunying, Wu Xiangliang, Zhang Huan, Ren Jingnan, Lu Liyun, Ma Huimin, Jin Dingping, Patch Michelle, Feng Xiuqin

Abstract excerpt

BACKGROUND: Heat stroke is a life-threatening condition demanding rapid core temperature reduction. However, optimizing cooling strategies is challenging due to pronounced patient heterogeneity. This study aimed to identify distinct clinical phenotypes of heat stroke to enable personalized cooling management. METHODS: This two-stage study analyzed heat stroke patients from seven tertiary hospitals in China. The...

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Identifiers

PMID: 42163368
DOI: 10.1186/s12967-026-08284-x
PMCID: PMC13371468

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