Quality over quantity: biopsy-anchored CT radiogenomics models outperform all-lesion training in a multi-tumour cohort despite a smaller sample size.

doi:10.1007/s00330-026-12601-9

Article

Quality over quantity: biopsy-anchored CT radiogenomics models outperform all-lesion training in a multi-tumour cohort despite a smaller sample size.

European radiology - 1 Oct 2026

Rodríguez Sánchez Diana Ivonne, Middelkoop Julian, Vanneste Thera, Maxouri Olga, Ursprung Stephan, Rostami Sajjad, Bogveradze Nino, Chupetlovska Kalina, Castagnoli Francesca, Landolfi Federica, Hong Eun Kyoung, Delli Pizzi Andrea, Gennaro Nicolo, Jutidamrongphan Warissara, Petrychenko Liliana, Snaebjornsson Petur, Bodalal Zuhir, Beets-Tan Regina

Abstract excerpt

OBJECTIVE: Radiogenomics aims to non-invasively predict tumour genotypes from imaging, but most studies assume molecular homogeneity by assigning a single biopsy-derived label to all lesions within a patient. This approach risks substantial label noise given well-documented interlesional heterogeneity. We investigated whether anchoring training to biopsy-confirmed lesions improves radiogenomic model performance...

Read the complete abstract on PubMed

Topics

Humans
Tomography, X-Ray Computed
Female
Retrospective Studies

Quality over quantity: biopsy-anchored CT radiogenomics models outperform all-lesion training in a multi-tumour cohort despite a smaller sample size.

Abstract excerpt

Topics

Related research