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Expanding HPV-Related Multiphenotypic Sinonasal Carcinoma Morphologic and Genotyping Profile: A Clinicopathological Study of 52 Latin American Cases.

The American journal of surgical pathology - 1 Jun 2026

Gonçalves de Paiva João P, Carrinho Ayroza Rangel Ana L, Epaminondas Silva de Araújo João, Medeiros Pacheco de Andrade Maíra, Lima Fernandes Igor, Faria Abrahao-Machado Lucas, Bishop Justin A, Jorge Jacks, Soares Ciro D

Abstract excerpt

This study characterized a cohort of 52 cases of HPV-related multiphenotypic sinonasal carcinoma (HMSC) from Latin America, integrating clinicopathological, immunohistochemical, HPV genotyping, and prognostic data. HMSC predominantly arose in the nasal cavity (n=20/38.46%) of patients in their sixth decade, with equal sex distribution (n=26/50%) and frequent symptomatic presentation. Histopathologically, all...

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PMID: 42124445
DOI: 10.1097/PAS.0000000000002526

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