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Article

Ecological factors and genetic features are associated with ecological generalism in pathogenic tick-borne viruses.

Nature communications - 11 May 2026

Ni Xue-Bing, Ye Yong-Tao, Wang Gong-Pei, Cheng Ye-Xiao, Wu Yu-Qian, Song Yi, Zhang Jin-Jin, Zhao Ning-Qi, Li Xin, Chen Dong-Sheng, Xiong Tao, An Tian-Feng, Chen Zi-Yun, Fang Zhong-Ze, Holmes Edward C, Cao Wu-Chun, Jia Na, Lam Tommy Tsan-Yuk

Abstract excerpt

Emerging and re-emerging tick-borne viruses (TBVs) have caused numerous outbreaks recently, yet the factors driving their emergence and pathogenicity in humans remain poorly understood across viral taxa. A large-scale analysis integrating epidemiological and genomic data of pathogenic TBVs reveal that highly pathogenic TBVs (HPTBVs) tend to exhibit ecological generalism. Specifically, HPTBVs infect a broader...

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PMID: 42115170
DOI: 10.1038/s41467-026-72514-5
PMCID: PMC13376358

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