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Article

Natural history of hearing loss in adults with mucopolysaccharidoses across phenotype and genotype.

Molecular genetics and metabolism - 1 Jul 2026

McCarron Eamon P, Stepien Karolina M, Summerfield Neil, Sharma Reena, Jovanovic Ana, Gossan Nicole, Burkitt-Wright Emma, Gadepalli Chaitanya

Abstract excerpt

BACKGROUND: Hearing loss is a recognised complication of mucopolysaccharidoses (MPS), but adult-specific data on long-term auditory outcomes remain limited. We aimed to characterise the adult natural history of hearing loss across MPS subtypes, including prevalence, severity, and longitudinal trajectory, and to explore associations with phenotype, genotype, and treatment exposure. METHODS: This retrospective...

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Identifiers

PMID: 42107344
DOI: 10.1016/j.ymgme.2026.110140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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