Signal peptide peptidase-like proteases OsSPPL1 and OsSPPL2 facilitate ER-associated protein degradation in rice.

Abstract excerpt

Signal peptide peptidases (SPPs) play a critical role in intramembrane proteolysis of signal peptides in mammals. However, their function in plants remains poorly understood. Here, we uncover the critical role of two rice SPP-like proteins, OsSPPL1/ 2, in ER-associated degradation (ERAD). Their expression is directly upregulated by OsbZIP50 under ER stress conditions. Mutations in OsSPPL1/2 result in increased ER...

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