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Article

A Whole-Exome Sequencing-Based Exploration of Chronic Kidney Disease of Unknown Etiology (CKDu) in an Endemic Population in Sri Lanka.

International journal of molecular sciences - 9 Apr 2026

Tom Wesley, Weerakoon Chiran, Fernando Nirmalee, Hasantha Isuru, Bandara Manoj, Krzyzanowski Gary, Nanayakkara Shanika, Cosgrove Dominic, Nanayakkara Nishantha, Fernando M Rohan

Abstract excerpt

A distinct form of chronic kidney disease of unknown etiology (CKDu) has emerged in tropical regions of Sri Lanka, predominantly affecting individuals aged 30-60 years in the North Central Province. Unlike conventional chronic kidney disease (CKD), CKDu occurs independently of diabetes or hypertension and is characterized by tubulointerstitial damage, including tubular atrophy, interstitial inflammation, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42074016
DOI: 10.3390/ijms27083369
PMCID: PMC13116950

Genes

ATXN3
LFNG
PNLDC1
FIP1L1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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