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Whole-exome sequencing reveals genetic variants associated with chronic kidney disease characterized by tubulointerstitial damages in North Central Region, Sri Lanka.

Environmental health and preventive medicine - 1 Sept 2015

Nanayakkara Shanika, Senevirathna S T M L D, Parahitiyawa Nipuna B, Abeysekera Tilak, Chandrajith Rohana, Ratnatunga Neelakanthi, Hitomi Toshiaki, Kobayashi Hatasu, Harada Kouji H, Koizumi Akio

Abstract excerpt

OBJECTIVES: The familial clustering observed in chronic kidney disease of uncertain etiology (CKDu) characterized by tubulointerstitial damages in the North Central Region of Sri Lanka strongly suggests the involvement of genetic factors in its pathogenesis. The objective of the present study is to use whole-exome sequencing to identify the genetic variants associated with CKDu. METHODS: Whole-exome sequencing of...

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Identifiers

PMID: 26108971
DOI: 10.1007/s12199-015-0475-1
PMCID: PMC4550612

Genes

LAMB2
KCNA10

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