Article
A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B.
Nature communications - 1 May 2026
Arii Jun, Aktar Salma, Huang Jing Rin, Hirai Mansaku, Kawamura Yoshiki, Miura Hiroki, Wang Bochao, Nagamata Satoshi, Nishimura Mitsuhiro, Yoshikawa Tetsushi, Harris Reuben S, Mori Yasuko
Abstract excerpt
Human herpesviruses exhibit diverse pathogenic outcomes and the molecular reasons are not fully understood. Human herpesvirus 6B (HHV-6B) causes exanthema subitum and encephalitis, whereas the closely related HHV-6A is typically asymptomatic. Here, we show that cellular APOBEC3 enzymes restrict HHV-6A replication but not HHV-6B. HHV-6B expresses higher levels of the U28 protein, which binds multiple APOBEC3...
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