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Article

Granuloprival cerebellar cortical degeneration in a mixed breed dog with an EMC1 mutation.

Journal of comparative pathology - 1 Jun 2026

Shekelle Kristen L, Martin Kian S, Boudreau Beth, Bryan Laura K

Abstract excerpt

A mixed-breed male puppy had a 6-month history of progressive cerebellar ataxia and head tremors without a clinically detectable cause. Euthanasia with a necropsy was elected based on the severity of the puppy's clinical signs and lack of response to treatment. At necropsy, the cerebellum was mildly atrophied, and microscopically there was severe diffuse loss of the cerebellar internal granular cell layer with...

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Identifiers

PMID: 42066428
DOI: 10.1016/j.jcpa.2026.04.009

Genes

EMC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Granuloprival cerebellar cortical degeneration in a mixed breed dog with an EMC1 mutation.PMID 42066428Read ↗

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