Pathologies at the gateway: exploring the link between nucleoporins and inherited diseases.

Abstract excerpt

Nuclear pore complexes serve as essential gatekeepers of the nuclear envelope, playing crucial roles in regulating transport across the nuclear envelope and maintaining compartmentalization between the nucleus and cytoplasm. While they are fundamental to all nucleated cells, the nucleoporins that make up these complexes are associated with various inherited diseases, often affecting specific cells, tissues, or...

Topics

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• Active Transport, Cell Nucleus
• Autoimmune Diseases
• Genetic Diseases, Inborn
• Mutation
• Neoplasms