TP53 genetic alterations are highly recurrent in Epstein-Barr virus-negative aggressive NK-cell leukemia: insights from an institutional experience and comprehensive literature review.

Abstract excerpt

OBJECTIVE: The differences between EBV-positive and EBV-negative aggressive NK-cell leukemia (ANKL) remain po orly understood. Herein, we sought to investigate the clinicopathologic and molecular differences between EBV-positive and EBV-negative ANKL. METHODS: We retrospectively analyzed 14 ANKL cases (9 EBV-positive, 5 EBV-negative), assessing clinicopathologic, cytogenetic, and mutational features. In addition,...

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