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Evolutionary analysis and immunoinformatic-based epitope prediction of dengue virus serotype 2 strains from Sri Lanka.

The Indian journal of medical research - 1 Mar 2026

Gunawardane Dilara Sesadi, Navarathna Amani, Kulasinghe Pasindu Akash, Jayakanth Thaksala Chamod, Dayananda Pavithra Dilakshini

Abstract excerpt

Background and objectives To investigate the phylogenetic and evolutionary relationships of dengue virus 2 (DENV-2) strains in Sri Lanka and identify probable antigenic B and T cell epitopes in the envelope gene region. Methods Phylogenetic analysis was conducted on the envelope gene region of Sri Lankan DENV-2 strains alongside globally homologous sequences. Selection pressure analysis identified codons under...

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Identifiers

PMID: 42024908
DOI: 10.25259/IJMR_2990_2025
PMCID: PMC13126523

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