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Article

Early prediction of gestational diabetes mellitus with clinical characteristics, cell-free DNA and genetic variants.

Journal of translational medicine - 21 Apr 2026

Chen Songchang, Wang Lulu, Zhu Qun, Wang Fan, Tang Chao, Zhang Bin, Shi Yi, Liu Mengdi, Liu Cong, Wang Yuling, Cao Xianling, Cheng Mengqiu, Peng Mindan, Yuan Yan, Kong Lingyin, Liang Bo, Shi Zhonghua, Huang Hefeng, Xu Chenming, Wu Yanting

Abstract excerpt

BACKGROUND: Gestational diabetes mellitus (GDM) remains a prevalent and heterogeneous pregnancy complication with limited strategies for early identification. We aimed to investigate efficient approaches for early prediction of GDM with clinical and genetic risk factors. METHODS: A previously developed machine-learning model based on clinical characteristics achieved an area under the curve (AUC) of 0.77. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42015270
DOI: 10.1186/s12967-026-08136-8
PMCID: PMC13137655

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