Article
A naturally synonymous mutation modulates an ERK-centered regulatory network to mediate thermotolerance divergence in Crassostrea oysters.
Communications biology - 20 Apr 2026
Wang Min, Wang Chaogang, Du Mingyang, Jiang Zhuxiang, Chen Jincheng, Pang Meiqian, Zhang Taiping, Cong Rihao, Wang Wei, Zhang Guofan, Li Li
Abstract excerpt
Kinase-mediated phosphorylation is crucial for thermal adaptation. While extracellular signal-regulated kinase 1/2 (ERK1/2) signaling is well characterized in model organisms, its functional divergence and genetic regulation in marine species with distinct thermal adaptations remain poorly understood. In this study, we investigated the genetic basis of differential ERK activation under heat stress using two...
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