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Article

Novel Basophilic Crystals in Acute Myeloid Leukemia with EZH2/DNMT3A Mutations: Aggressive Case with Thrombosis.

Clinical laboratory - 1 Apr 2026

Liu Zhiqing, He Dong, Wen Xinglin, Xu Song, Xiao Dejun

Abstract excerpt

BACKGROUND: This study reports a novel case of EZH2/DNMT3A-mutated AML featuring unique basophilic rectangular crystals in blasts, associated with aggressive disease and thrombotic complications. METHODS: A 56-year-old male underwent morphological analysis (light microscopy, cytochemistry), clinical monitoring, and molecular profiling. RESULTS: MPO-negative rectangular crystals (3 - 20 µm) persisted despite...

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Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3A

Share to Enhancer of Zeste Homolog 2 Protein

Share to Epigenesis, Genetic

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Share to Leukemia, Myeloid, Acute

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Source

Identifiers

PMID: 41979630
DOI: 10.7754/Clin.Lab.2025.250653

Genes

DNMT3A
MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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