The Impact of Post-Transplant Interventions and Chronic GVHD on Survival in Myeloid Malignancies Harboring TP53 Alterations.

doi:10.1016/j.jtct.2026.03.039

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The Impact of Post-Transplant Interventions and Chronic GVHD on Survival in Myeloid Malignancies Harboring TP53 Alterations.

Transplantation and cellular therapy - 1 Jul 2026

Ellithi Moataz, Raj Sandeep, Bromberg Maria, Goldstein Ilan, Saldia Amethyst, Papadopoulos Esperanza B, Gyurkocza Boglarka, Ponce Doris M, Shaffer Brian C, Tamari Roni, Young James W, Politikos Ioannis, Shah Gunjan L, Alhomoud Mohammad, Raju Gagan, Hughes Charlotte F M, Dahi Parastoo B, Scordo Michael, Giralt Sergio A, Perales Miguel-Angel, Goldberg Aaron D, Berman Ellin, Wang Xin, Stein Eytan M, Gonen Mithat, Jakubowski Ann A, Lin Richard J

Abstract excerpt

Myeloid malignancies with TP53 alterations are characterized by genomic instability, chemotherapy resistance, and very poor outcomes even after allogeneic hematopoietic cell transplantation (allo-HCT). Hypomethylating agents (HMAs), small molecule targeted therapies, and donor lymphocyte infusion (DLI) are often used post-transplant to mitigate relapse risk in high-risk myeloid malignancies, but their impact on...

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PMID: 41974306
DOI: 10.1016/j.jtct.2026.03.039
PMCID: PMC13200698

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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