Article
Tandem Mass Spectrometry Fingerprint Tags (TMSFT) Applied for Early Gestation Noninvasive Prenatal Detection of Single-Gene Disorders.
Analytical chemistry - 28 Apr 2026
Zhu Fei, Qiao Yimeng, Guo Xuan, Li Xin, Li Qing, Zhang Lanlan, Zhao Zhenhua, Wang Ting, He Lin, Wang Kun, Hu Yuhong, Shao Zhen, Kong Xiangdong, Li Tongchuan, Xing Qinghe, Zhou Feng
Abstract excerpt
Noninvasive prenatal testing for single-gene disorders faces significant challenges due to low fetal DNA abundance in maternal blood, particularly in early gestation. Although next-generation sequencing (NGS) is widely used, it frequently encounters false-negative outcomes and high costs when detecting low-abundance fetal variants. To address these limitations, we developed a highly sensitive and cost-effective...
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