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Article

Genetic background is associated with distinct patterns of proarrhythmogenic remodeling leading to atrial fibrillation in pigs with ischemic heart failure.

Basic research in cardiology - 1 Jun 2026

Zhang Zhihao, Vlcek Julia, Heger Christina, Pauly Valerie, Hesse Nora, Schüttler Dominik, Merkus Daphne, Wolf Eckhard, Medugorac Ivica, Kääb Stefan, Tomsits Philipp, Clauss Sebastian

Abstract excerpt

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, driven by electrical and structural remodeling that promotes proarrhythmic substrates. Interindividual variability in susceptibility to remodeling triggers, such as myocardial ischemia, suggests the involvement of genetic determinants. Ischemic heart failure (IHF) was induced by a 90-min occlusion of the left anterior descending artery in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41951797
DOI: 10.1007/s00395-026-01176-7
PMCID: PMC13186903

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MMP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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