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Article

Population-genomic stability of a closed-herd GGTA1-knock-out miniature pig line for xenotransplantation.

Laboratory animals - 1 Jun 2026

Lee Won Kil, Kim Sang Eun, Seo Dongwon, Lee Seunghoon, No Jin-Gu, Kim Seokho, Do Min Hwa, Lee Joo Young, Hyeong Namwoong, Lee Hwi-Cheul, Lee Poongyeon, Oh Keon Bong

Abstract excerpt

Genetically engineered pigs are essential donors for xenotransplantation, requiring phenotypic stability and genetic definition. We evaluated the newly established GGTA1-knock-out "XENO" line, maintained as a closed herd for >10 generations, against Massachusetts General Hospital (MGH) miniature swine, commercial Landrace (LR), and Yorkshire × Landrace (Y × L) populations. One hundred and thirty-nine pigs were...

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Share to Animals, Genetically Modified
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41947624
DOI: 10.1177/00236772261432004

Genes

GGTA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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