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Article

Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology.

The Journal of molecular diagnostics : JMD - 1 Jun 2026

Carta Maria Giulia, Tögel Lars, Hölsken Annett, Schubart Christoph, Sticht Heinrich, Stöhr Robert, Spoerl Silvia, Meidenbauer Norbert, Hartmann Arndt, Magni Paolo, Haller Florian, Ferrazzi Fulvia

Abstract excerpt

Accurate and reproducible interpretation of somatic variants is fundamental for therapy decision-making in patients with cancer. To harmonize and automate oncogenicity classification, Oncogenicity Variant Interpreter (OncoVI), an open-source, Python-based implementation of the Clinical Genome Resource/Cancer Genomics Consortium/Variant Interpretation for Cancer Consortium oncogenicity guidelines, was developed....

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Identifiers

PMID: 41936821
DOI: 10.1016/j.jmoldx.2026.03.004
PMCID: PMC13269341

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