Article
External Quality Assessment on Molecular Tumor Profiling with Circulating Tumor DNA-Based Methodologies Routinely Used in Clinical Pathology within the COIN Consortium.
Clinical chemistry - 2 May 2024
van der Leest Paul, Rozendal Pim, Hinrichs John, van Noesel Carel J M, Zwaenepoel Karen, Deiman Birgit, Huijsmans Cornelis J J, van Eijk Ronald, Speel Ernst Jan M, van Haastert Rick J, Ligtenberg Marjolijn J L, van Schaik Ron H N, Jansen Maurice P H M, Dubbink Hendrikus J, de Leng Wendy W, Leers Mathie P G, Tamminga Menno, van den Broek Daan, van Kempen Léon C, Schuuring Ed
Abstract excerpt
BACKGROUND: Identification of tumor-derived variants in circulating tumor DNA (ctDNA) has potential as a sensitive and reliable surrogate for tumor tissue-based routine diagnostic testing. However, variations in pre(analytical) procedures affect the efficiency of ctDNA recovery. Here, an external quality assessment (EQA) was performed to determine the performance of ctDNA mutation detection work flows that are...
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