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Article

The MTHFR C677T polymorphism and protection against Legg-Calvé-Perthes disease in children: an updated systematic review and meta-analysis.

Orphanet journal of rare diseases - 3 Apr 2026

Hemmatyar Ahmad, Dastgheib Alireza, Shahbazi Amirhosein, Bahrami Reza, Golshan-Tafti Mohammad, Rahmani Amirhossein, Shiri Amirmasoud, Aghili Kazem, Massoudi Ali, Ekraminasab Sedigheh, Sheikhpour Elnaz, Neamatzadeh Hossein

Abstract excerpt

BACKGROUND: Legg-Calvé-Perthes disease (LCPD) is a multifactorial pediatric hip disorder with complex genetic underpinnings. The methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) polymorphism influences folate metabolism and vascular function and has been investigated as a potential genetic modifier of LCPD susceptibility, though individual study findings remain inconsistent. METHODS: A comprehensive...

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Case-Control Studies
Child
MAF gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Methylenetetrahydrofolate Reductase (NADPH2)

Polymorphism, Single Nucleotide

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Identifiers

PMID: 41933355
DOI: 10.1186/s13023-026-04325-2
PMCID: PMC13173826

Genes

MTHFR
MAF
VIP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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