Clinical Insights Into the COL4A3 p.Gly407Arg Variant in Alport Syndrome.

Abstract excerpt

KEY POINTS: Phenotypic variability remains significant among patients with the monoallelic COL4A3 p.Gly407Arg variant, despite shared environmental backgrounds. Proteinuria ≥500 mg/g is a strong predictor of renal function decline and adverse outcomes, highlighting its value as a key prognostic marker. Early nephrologic monitoring and timely initiation of renoprotective therapies, such as...

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