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Article

Time-associated phenotypic changes related to virulence and immune interaction of Staphylococcus aureus during relapsing infection within individual hosts.

BMC infectious diseases - 1 Apr 2026

Wang Jiaao, Tu Shangyu, Wu Wanyun, Zhang Li, Liu Si, Zhang Xiaoyang, Li Bowen, Zhang Yawei, Zhao Chunjiang, Wang Xiaojuan, Wang Qi, Wang Hui, Chen Hongbin

Abstract excerpt

BACKGROUND: Staphylococcus aureus is a major cause of relapsing infection. However, how its phenotypic traits change over time within individual hosts during relapsing infection remains incompletely characterized. METHODS: In this study, we analyzed five longitudinal S. aureus isolates obtained from two patients with relapsing infection to investigate within-host phenotypic and genomic changes. Whole-genome...

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Identifiers

PMID: 41922994
DOI: 10.1186/s12879-026-13214-9
PMCID: PMC13169561

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