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Article

Single-cell phenotypic heterogeneity shapes quorum signaling dynamics in Pseudomonas aeruginosa.

Nature communications - 31 Mar 2026

Lange Danielle G, Litvinov Vadim, Dar Daniel

Abstract excerpt

Quorum sensing (QS) coordinates collective bacterial behavior, yet how individuality arises within a system built to unify action remains unclear. Using imaging-transcriptomics, we profile the QS response of Pseudomonas aeruginosa at single-cell resolution and uncover heterogeneity across all stages of QS. We find that most cells cooperate, but their contributions vary widely due to transcriptional noise. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41917010
DOI: 10.1038/s41467-026-71109-4
PMCID: PMC13199524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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