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Article

Spatial transcriptomics of planktonic and sessile bacterial populations at single-cell resolution.

Science (New York, N.Y.) - 13 Aug 2021

Dar Daniel, Dar Nina, Cai Long, Newman Dianne K

Abstract excerpt

Capturing the heterogeneous phenotypes of microbial populations at relevant spatiotemporal scales is highly challenging. Here, we present par-seqFISH (parallel sequential fluorescence in situ hybridization), a transcriptome-imaging approach that records gene expression and spatial context within microscale assemblies at a single-cell and molecule resolution. We applied this approach to the opportunistic pathogen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34385369
DOI: 10.1126/science.abi4882
PMCID: PMC8454218

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