Article
O2a O-antigen type and sepsis in invasive Klebsiella pneumoniae: evidence of association and clustering with an ST11-K64/CRKP background in a retrospective cohort.
Frontiers in cellular and infection microbiology - 1 Jan 2026
Li Mengyan, Gu Minghao, Wang Hong, Sun Yi, Jiang Shan, Wang Xiangke, Wang Shengyao, Wang Mingyu, Lv Sensen, Han Xiudi, Liu Xuedong
Abstract excerpt
Background: Invasive Klebsiella pneumoniae (KP) infections complicated by sepsis are often associated with substantial mortality, which may partly result from dysregulated host immune-inflammatory responses to bacterial components, including lipopolysaccharide. KP O-antigen types have gained increasing attention in epidemiological surveillance and vaccine development, yet their relationship with sepsis risk in...
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