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Article

Divergent Associations of the VEGF (-2578C/A) Polymorphism with Imaging-Based Severity and Symptom Profile of Adenomyosis in Infertile Women: An Exploratory Analysis.

Medicina (Kaunas, Lithuania) - 19 Mar 2026

Surcel Mihai, Iancu Mihaela, Rotar Ioana Cristina, Goidescu Iulian, Staicu Adelina, Nemeti Georgiana, Boitor-Borza Dan, Lucaciu Roxana Liana, Hangan Adriana Corina, Mureșan Daniel, Procopciuc Lucia Maria

Abstract excerpt

Background and Objectives: Adenomyosis is increasingly being recognized as a heterogeneous uterine disorder with variable clinical expressions. Current ultrasound-based classifications do not consistently align structural severity with symptom burden. Given its role in angiogenesis, inflammation, and endometrial remodeling, vascular endothelial growth factor (VEGF) signaling may influence both morphological...

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PMID: 41901652
DOI: 10.3390/medicina62030571
PMCID: PMC13027807

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