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Genomic Biomarkers and Mutational Landscape of Nonsyndromic Hearing Loss (NSHL) in the Singaporean Population: Clinical Translational Implications.

Biomolecules - 26 Feb 2026

Lim Che Kang, Cheng Mei Shuang, Low Gerard, Tang Joyce Zhi'en, Ng Jia Hui, Ong Ni Gin, Leem Pei Shan, Lim Su Ann, Thong Jiun Fong, Tan Vanessa Yee Jueen

Abstract excerpt

Nonsyndromic hearing loss (NSHL) is a highly prevalent, genetically heterogeneous condition, yet its molecular basis in the Singaporean population remains underexplored. We performed whole-exome sequencing and integrative bioinformatics analysis in 115 patients with NSHL to define population-specific genetic biomarkers. A molecular diagnosis was achieved in 57% of cases, with 76% of identified variants classified...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41897287
DOI: 10.3390/biom16030352
PMCID: PMC13024665

Genes

GJB2
MYO6
SLC26A4
ACTG1
CEACAM16
COL11A2
DIAPH1
MYH14
MYO15A
MYO7A
OTOF
SLC17A8
SMPX
STRC
TJP2
TMC1
TMPRSS3
TNC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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