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Article

Unraveling the genetic basis of post-infancy diagnosed sensorineural hearing loss using whole exome sequencing.

Hearing research - 1 Dec 2025

Li Weitao, Yu Sha, Zhu Biyun, Chen Liheng, Li Huawei, Guo Luo, Shu Yilai, Chen Bing

Abstract excerpt

OBJECTIVE: To clarify the genetic causes and the mutation spectrum of post-infancy diagnosed sensorineural hearing loss in the Chinese population. METHODS: We enrolled patients with post-infancy diagnosed bilateral sensorineural hearing loss (onset age between 1 and 60 years) at the Eye & ENT Hospital of Fudan University from November 2018 to October 2022. Whole-exome-sequencing (WES) was performed to elucidate...

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Identifiers

PMID: 41115328
DOI: 10.1016/j.heares.2025.109455

Genes

GJB2
MPZL2
SLC26A4

Variants

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