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Article

TSPO-PET highlights an atypical mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) phenotype.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 26 Mar 2026

Zeng Yang, Yang Yingxue, Wang Wei, Peng Qing, Bai Yuye, Yu Xiaoling, Yang Shen, Ren Liankun

Abstract excerpt

BACKGROUND: The m.10158T > C mutation in the mitochondrial gene (MT-ND3) is a rare cause of adult-onset mitochondrial encephalopathy, typically presenting as MITOCHONDRIAL ENCEPHALOMYOPATHY WITH LACTIC ACIDOSIS AND STROKE-LIKE EPISODES (MELAS) with predominant cortical involvement. Early cerebellar onset and progressive atrophy are atypical. To investigate the underlying pathophysiology, we innovatively applied...

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Identifiers

PMID: 41882155
DOI: 10.1007/s10072-026-08998-2

Genes

TSPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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