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Comprehensive E2 gene-based phylogeny uncovers emerging lineages and refines global genotype framework of classical swine fever virus.

Virology - 1 Jun 2026

Patil Sharanagouda Shiddanagouda, Harish Jayaramareddy, Ramakrishna Ganesh Kothapete, Suresh Kuralayanapalya Puttahonnappa, Hiremath Jagadish, Nayakvadi Shivasharanappa

Abstract excerpt

This study presents a comprehensive phylogenetic reclassification of classical swine fever virus (CSFV) genotypes based on E2 gene analysis of 558 isolates collected worldwide between 1951 and 2024. The E2 gene, a major antigenic determinant, was used to reconstruct evolutionary relationships and refine the global genotype framework. Phylogenetic analysis confirmed the validity of the major genotypes (1-5) while...

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PMID: 41880900
DOI: 10.1016/j.virol.2026.110875

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