Article
DNA methylation site loss for plasticity-led novel trait genetic fixation.
Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 2026
Katsumura Takafumi, Sato Suguru, Yamashita Kana, Oda Shoji, Gakuhari Takashi, Tanaka Shodai, Fujitani Kazuko, Nishimaki Toshiyuki, Imai Tadashi, Yoshiura Yasutoshi, Takeshima Hirohiko, Hashiguchi Yasuyuki, Sekita Yoichi, Mitani Hiroshi, Ogawa Motoyuki, Takeuchi Hideaki, Oota Hiroki
Abstract excerpt
Phenotypic plasticity allows organisms to adapt traits in response to environmental changes, yet the molecular basis by which such plastic traits become genetically fixed remains unclear. Here, we investigated gut-length plasticity in medaka fish (Oryzias latipes) through genome-wide methylation profiling, CRISPR/Cas9-mediated deletion, and population genomic analyses. We found that seasonal methylation of CpG...
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