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Article

Multinodular and vacuolating neuronal tumor: molecular genetics and DNA methylation analysis of 12 cases.

The Journal of pathology - 1 Jul 2026

Lian Fang, Wang Dan-Dan, Gong Jing, Luo Tao, Guo Lin-Ai, Wang Wei-Min, Chen Ni, Yao Xiao-Hong, Piao Yue-Shan

Abstract excerpt

Multinodular and vacuolating neuronal tumor (MVNT) was recognized as a distinct neuronal tumor entity in the revision of the 2021 World Health Organization (WHO) Classification of Tumors of the CNS. In this study, we retrospectively analyzed 12 surgical cases, two of which exhibited ganglioglioma (GG)-like components. The cohort consisted of eight male and four female patients, with a median age of 31 years (age...

Topics

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Adolescent
Biomarkers, Tumor
Brain Neoplasms
DNA Methylation
Ganglioglioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41879092
DOI: 10.1002/path.70056

Genes

BRAF
FGFR2
BCAN
EGFR
GFAP
IDH1
IDH2
INA
MAP2
MAP2K1
NTRK1
OLIG2
SOX10
TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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