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Article

Genetic evidence for a causal protective effect of GLP-1 receptor agonists on paralytic ileus but not on other gastrointestinal events.

Medicine - 20 Mar 2026

Yuan Bo, Yang Zhao, Wang Chenmiao, Zong Geng, Qiu Jing, Feng Chengwu, Geng Xin

Abstract excerpt

The association between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and gastrointestinal events remains controversial in observational studies. To address this, our study employed drug-target Mendelian randomization (MR) to investigate the causal relationship between GLP-1RAs and 24 gastrointestinal disorders, supplemented by sensitivity analyses, Cox proportional hazards regression analysis and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41861181
DOI: 10.1097/MD.0000000000048089
PMCID: PMC13008193

Genes

GLP1R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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