Risk factors and surrogate indicators for cardiovascular disease are prevalent in Common Variable Immunodeficiency and associate with inflammatory phenotype.

doi:10.3389/fimmu.2026.1756049

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Article

Risk factors and surrogate indicators for cardiovascular disease are prevalent in Common Variable Immunodeficiency and associate with inflammatory phenotype.

Frontiers in immunology - 1 Jan 2026

Yu Aidan Jia Sheng, Moreira Fernando, Symes Andrew, Curlewis Keegan, O'Sullivan Mary, Jayasundera Joseph, El Rhermoul Fatema-Zahra, Lever Charley, Stoenchev Kostadin, Chow Ke Li, Uysal Omer Faruk, Alharbi Ahmad M, Workman Sarita, Halliday Neil, Laurence Arian, Verma Nisha, Tadros Susan, Kiani-Alikhan Sorena, Barnett Joseph, Burns Siobhan O, Hurst John R, Lowe David M

Abstract excerpt

Background: Common variable immunodeficiency (CVID) is traditionally characterised by recurrent infections and immune dysregulation, but growing evidence suggests an increased risk of endothelial dysfunction and premature atherosclerosis in this population. Objective: To evaluate cardiovascular risk in patients with CVID through integration of clinical risk factors, biomarkers of endothelial dysfunction, and...

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PMID: 41846912
DOI: 10.3389/fimmu.2026.1756049
PMCID: PMC12989573

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