Phenotypic modulation of corpus cavernosum smooth muscle cells in type 2 diabetic rats is mediated by regulated exosomes secretion via neutral sphingomyelinase-2.

doi:10.4103/aja202569

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Phenotypic modulation of corpus cavernosum smooth muscle cells in type 2 diabetic rats is mediated by regulated exosomes secretion via neutral sphingomyelinase-2.

Asian journal of andrology - 1 Sept 2026

Chen Feng-Zhi, Zhang Xin-Tao, Zeng Qin-Yu, Lu Bing-Xin, Wang Li, Mei Hong-Bing, Wei An-Yang

Abstract excerpt

Phenotypic modulation of corpus cavernosum smooth muscle cells (CCSMCs) is closely related to the occurrence of erectile dysfunction (ED). However, the effect of exosomes (EXOs) on the phenotypic modulation of CCSMCs with diabetes mellitus (DM)-related ED is not fully understood. Using a rat model of type 2 DM, we found an important role for phenotypic modulation of CCSMCs in DM-related ED. EXO secretion by...

Read the complete abstract on PubMed

Topics

Animals
Male
Exosomes
Sphingomyelin Phosphodiesterase
Rats
Penis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Myocytes, Smooth Muscle

Diabetes Mellitus, Type 2

Diabetes Mellitus, Experimental

Phenotype

Rats, Sprague-Dawley

Erectile Dysfunction

Cells, Cultured

Becaplermin

Source

Open in PubMed Open full text

Identifiers

PMID: 41846426
DOI: 10.4103/aja202569
PMCID: PMC13623336

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic modulation of corpus cavernosum smooth muscle cells in type 2 diabetic rats is mediated by regulated exosomes secretion via neutral sphingomyelinase-2.PMID 41846426Read ↗

Characterization of corpus cavernosum smooth muscle cell phenotype in diabetic rats with erectile dysfunction.Semantic proximity Read ↗

[CRISPR/Cas9-mediated TEAD1 knockout induces phenotypic modulation of corpus cavernosum smooth muscle cells in diabetic rats with erectile dysfunction].Semantic proximity Read ↗

[henotypic modulation of corporal cavernosum smooth muscle cells and erectile dysfunction: Advances in studies].Semantic proximity Read ↗

[Calcitonin gene-related peptide induces phenotypic transformation of corpus cavernosum smooth muscle cells in diabetic rats with erectile dysfunction].Semantic proximity Read ↗

[Phenotypic modulation of corpus cavernous smooth musle cells and its influencing factors].Semantic proximity Read ↗

Maintenance of the contractile phenotype in corpus cavernosum smooth muscle cells by Myocardin gene therapy ameliorates erectile dysfunction in bilateral cavernous nerve injury rats.Semantic proximity Read ↗

Bladder smooth muscle cell phenotypic changes and implication of expression of contractile proteins (especially caldesmon) in rats after partial outlet obstruction.Semantic proximity Read ↗

[Phenotypic transformation of corpus cavernosum smooth muscle cells in hypertensive rats].Semantic proximity Read ↗

N-acetylcysteine ameliorates erectile dysfunction in rats with hyperlipidemia by inhibiting oxidative stress and corpus cavernosum smooth muscle cells phenotypic modulation.Semantic proximity Read ↗

[Phenotypic modulation of bladder smooth muscle in diabetic rats].Semantic proximity Read ↗

Exosomes derived from mesenchymal stem cells exert therapeutic effect in a rat model of cavernous nerves injury.Semantic proximity Read ↗

Sphingomyelin metabolism is involved in the differentiation of MDCK cells induced by environmental hypertonicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.