Multi-omics feature engineering driven by biomedical foundation models improves drug response prediction for inflammatory bowel disease patients.

Abstract excerpt

Using biomedical foundation models (FMs) for inference on small cohorts, represents a promising and practical route to advance drug response biomarker discovery and target identification. Here, we demonstrate this via an innovative data-driven inference workflow, using a fine-tuned, biomedical FM. We study multi-omics (genomic, transcriptomic) data and predict pharmacological responses, both from surgical...

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