Article
Genotype-phenotype correlation-driven precision management in hereditary conductive and mixed hearing loss.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery - 1 Jun 2026
Wang Qin, Wu Xiedong, Dong Guojie, Li Xiaoge, Gu Xiaoning, Lin Rongfeng, Sun Shihan, Sun Dance, Shen Weidong, Han Dongyi, Dai Pu, Han Weiju, Ning Fei, Wang Guojian, Yuan Yongyi
Abstract excerpt
OBJECTIVE: To investigate genetic etiologies of conductive/mixed hearing loss (CHL/MHL) and guide management through genotype–phenotype correlations. METHODS: Retrospective study of 98 patients (29 syndromic, 69 non-syndromic) with CHL/MHL. Clinical evaluations and next-generation sequencing were performed. Surgical outcomes and familial patterns were analyzed. RESULTS: Syndromic cases showed high genetic...
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