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Article

Breast Cancer Disparities in African and African-Ancestry Populations: Genetics, Epigenetics, Structural Barriers and Technology-Enabled Solutions.

British journal of biomedical science - 1 Jan 2026

Eze Chika, Swadi Rasha, Ross Kehinde, Sharma Vijay

Abstract excerpt

Breast cancer remains a leading cause of mortality among women globally, with disproportionately high incidence, aggressive subtypes and poor outcomes in African and African-ancestry populations. While inherited BRCA1/BRCA2 mutations drive hereditary risk, recent evidence highlights the critical role of BRCA1 promoter methylation especially in sporadic and triple-negative breast cancers (TNBC), which...

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Source

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Identifiers

PMID: 41836332
DOI: 10.3389/bjbs.2026.16013
PMCID: PMC12982158

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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