[Whole Exome Sequencing Identified Novel Pathogenic Mutations of ADGB in Patients With Oligoasthenozoospermia].

Abstract excerpt

Objective: To systematically analyze the mutation spectrum of the androglobin gene (ADGB) in infertile males and investigate the association between its genotypes and phenotypes related to male infertility, thereby elucidating the critical role of ADGB in male reproductive function. Methods: This study recruited 781 Chinese males diagnosed with primary infertility. Whole exome sequencing (WES) combined with...

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• Asthenozoospermia
• Exome Sequencing
• OAT gene
• Infertility, Male
• Mice