Article
Testing the performance of polygenic scores for multiple traits to explain cerebral palsy in two independent cohorts.
EBioMedicine - 1 Apr 2026
Thomas Jodi T, Berry Alexander S F, Oetjens Matthew T, Berry Jesia G, MacLennan Alastair H, Gordon Scott D, Hale Andrew T, Olsen Catherine M, Whiteman David C, Torene Rebecca I, Ledbetter David H, Martin Nicholas G, van Eyk Clare L, Gecz Jozef, Myers Scott M, Mitchell Brittany L, Corbett Mark A
Abstract excerpt
BACKGROUND: Cerebral palsy (CP) is a complex neurodevelopmental disorder with both environmental and genetic contributors. Rare genetic variants explain a substantial proportion of CP, but the contribution of common variants remains unclear. We evaluated whether polygenic scores for CP and related traits explain the aetiology of CP. METHODS: We analysed two independent target cohorts: a case-control cohort...
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