Article
Neurocognitive functioning, seizure control, and return to work after awake surgery with or without adjuvant therapy in IDH-mutant grade 3 diffuse gliomas.
Journal of neuro-oncology - 13 Mar 2026
Elia Angela, Roux Alexandre, Demasi Marco, Debacker Clément, Seneca Maïmiti, Dezamis Edouard, De France Gonzague, Trancart Bénédicte, Muto Jun, Oppenheim Catherine, Chrétien Fabrice, Zanello Marc, Pallud Johan
Abstract excerpt
PURPOSE: The optimal oncological management of adult patients with IDH-mutant CNS WHO grade 3 diffuse gliomas remains debated, particularly given the potential neurotoxic effects of adjuvant therapies on cognition and health-related quality-of-life. METHODS: We conducted a retrospective single-center cohort study including 87 consecutive patients with IDH-mutant CNS WHO grade 3 glioma who underwent awake...
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