Article
Metabolomic profiling of genotype-derived ABO blood group, secretor status, and Lewis antigens and association with pancreatic ductal adenocarcinoma risk.
American journal of epidemiology - 3 Jun 2026
Zhang Ting, Moore Steven C, Fu Sheng, Albanes Demetrius, Liao Linda M, Loftfield Erikka, Playdon Mary C, Weinstein Stephanie J, Yu Kai, Stolzenberg-Solomon Rachael Z
Abstract excerpt
The ABO locus is associated with pancreatic ductal adenocarcinoma (PDAC). Potential metabolic mechanisms underlying these associations have not been investigated. We examined associations between genotype-derived ABO blood group (rs505922 and rs8176746) and 1478 prediagnostic serum metabolites in 4042 participants from 8 nested case-control studies within the Prostate, Lung, Colorectal, and Ovarian Cancer...
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