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Article

Genetically predicted gut bacteria, circulating bacteria-associated metabolites and pancreatic ductal adenocarcinoma: a Mendelian randomisation study.

Scientific reports - 24 Oct 2024

Daniel Neil, Farinella Riccardo, Chatziioannou Anastasia Chrysovalantou, Jenab Mazda, Mayén Ana-Lucia, Rizzato Cosmeri, Belluomini Flavia, Canzian Federico, Tavanti Arianna, Keski-Rahkonen Pekka, Hughes David J, Campa Daniele

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) has high mortality and rising incidence rates. Recent data indicate that the gut microbiome and associated metabolites may play a role in the development of PDAC. To complement and inform observational studies, we investigated associations of genetically predicted abundances of individual gut bacteria and genetically predicted circulating concentrations of...

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Identifiers

PMID: 39448785
DOI: 10.1038/s41598-024-77431-5
PMCID: PMC11502931

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