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Article

Genetic variations interact with polybrominated diphenyl ether exposure to alter lipid homeostasis.

Nature communications - 5 Mar 2026

Hu Naifan, Li Bin, Lu Yifu, Jiang Qi, Zhu Ying, Li Zheng, Qu Yingli, Qiu Tian, Zhang Donghui, Wang Zhuo, Ma Yunfei, Jin Huibin, Sun Peijie, Song Haocan, Zhao Yunhao, Zhao Yifan, Zhang Ming, Zhao Feng, Ji Saisai, Yuan Bifeng, Zhu Ying, Lv Yuebin, Tian Jianbo, Miao Xiaoping, Shi Xiaoming

Abstract excerpt

Polybrominated diphenyl ethers (PBDEs) are implicated in dyslipidemia, but the molecular basis of individual susceptibility remains elusive. Here we report an analysis based on the China National Human Biomonitoring cohort, where we integrate exposome, genomic, and metabolomic data to identify 3,571 genetic variants that interact with PBDE exposure to influence dyslipidemia risk. Metabolomic analysis highlights...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41786719
DOI: 10.1038/s41467-026-70222-8
PMCID: PMC13087138

Genes

BHLHE40
SLC6A20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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